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Resection of a Large Skull Mass in a Golden Retriever
Dominik Faissler, Dr. med. vet., Dipl. ECVN Background A 5.6-year-old, neutered male, Golden Retriever presented for a one-week history with a firm mass on ...

Dominik Faissler, Dr. med. vet., Dipl. ECVN

Background

A 5.6-year-old, neutered male, Golden Retriever presented for a one-week history with a firm mass on the right side of the head. The mass was non-painful and based on palpation, appeared to be originating from the skull. The remainder of the physical examination and neurological examination were unremarkable.

History

In preparation for anesthesia, a Complete Blood Count (CBC) and serum chemistry profile were performed and showed normal blood parameters and normal metabolic, acid-base, and electrolyte function. Three view chest radiographs did not reveal evidence of metastatic disease. An ultrasound of the abdomen did not show any concurrent disease. Under general anesthesia, a computed tomography (CT) scan of the head was performed. The imaging study showed a right-sided, granular skull mass extending from the frontal sinus to the mid parietal and temporal bone. The mass was causing compression of the olfactory lobe, frontal lobe, and cortex of the parietal lobe. The mass measured 78 mm long, 52 mm wide, and 48 mm high at its maximal points. The calculated volume of the mass was 102 cm3 (Figure 1 and 2).

Question 1

What type of skull tumor is most likely and what additional test would you recommend confirming your suspicion?

The primary differentials for the mass included a multilobular osteochondrosarcoma (MLO) or a more aggressive osteosarcoma. The typical CT appearance of an MLO on a bone window includes a nonhomogeneous granular mass with well-defined margins. The normal bone will be destroyed by the tumor 1.  In contrast, an osteosarcoma contains more lytic and less defined areas with loss of mineralized bone structures and strong periosteal reactions. The osteosclerotic forms of an osteosarcoma can look very similar to an MLO and in general, a biopsy is recommended to confirm the diagnosis. The biopsy results in our patient confirmed the presence of an MLO also known as a multilobular tumor of the bone while ruling out an osteosarcoma. 

Question 2

What are the possible treatment options for an MLO?

MLO is the most common tumor of the skull in older, medium to large breed dogs. The biological behavior may range from benign to more malignant with 23% of the tumors being more aggressive. In malignant tumors, there is extensive local invasion of surrounding structures and the reported incidence of metastatic disease is as high as 56-58% 2,3. Typically, at the time of diagnosis, only a small to medium-sized skull exostosis is noted on physical examination. Later, advanced imaging (MRI or CT scan) often shows an extensive lesion which is widely dispersed throughout the skull and is often compressing multiple brain structures. Surgical resection is an optimal treatment choice in many cases 4 though tumor grade and completeness of resection are important prognostic factors that ultimately determine the long-term outcome. Two studies with a limited number of dogs with skull involvement reported a disease-free interval of 12 and a median survival time of 17.6 to 21 months after surgical resection 2,4. The most challenging part of a surgical resection is the reconstruction of the skull. Tumor removal leaves large skull defects and an exposed brain. Traditionally, the bone defects were covered with bone cement [Poly(methyl methacrylate) (PMMA)] implants 5. More recently, the use of titanium mesh and screws of the Low-Profile Neuro Plating System® (DePuy Synthes) has offered more repair options and a better integration of the implants into the remaining tissues 6,7. Radiation therapy alone can shrink the tumor volume anywhere between 26-87% but will not eliminate the mass. The reported median survival time for stereotactic radiation was 11 months 8. Chemotherapy has been shown to have a limited effect and median survival time was 4.8 months 9. A combination of surgical resection, skull reconstruction and definitive conventional radiation therapy produced an average survival time of 17.1 months 10.

Question 3

Is the 5.6 years old Golden retriever a good surgical candidate?

Based on this survival time information, surgical resection was planned for our patient. A normal metabolic function and the absence of metastatic disease made this dog a good candidate. A larger skull defect after tumor removal was expected but advanced skull reconstruction techniques made a closure of the gap very likely. The tumor was removed in two pieces due to its large size. Complete margins could not be safely achieved due to the extensive attachment and integration of the tumor to the brain, but the grossly defined portions of the mass were completely removed. The surface of exposed brain was covered with fascia of the temporal muscle. The skull surface and the frontal sinus was reconstructed with the Low-Profile Neuro Plating System® (DePuy Synthes). The titanium mesh was contoured to the previous skull shape (Figure 3). The reconstruction was covered with the temporal muscle and skin. The dog recovered well and was discharged 3 days after the procedure. The histopathological analysis confirmed a low grade MLO. Nine months after the procedure, the patient presented in excellent condition with a very good quality of life. Eleven months post-surgery the dog was still disease free (Figure 4).

 Literature

  1. Hatchcock JT, Newton JC. Computed tomographic characteristics of multilobular tumor of bone involving the cranium in 7 dogs and zygomatic arch in 2 dogs. Vet Radiol Ultrasound, 41:214-1217, 2000.
  2. Straw RC, LeCouteur RA, Powers BE, Withrow SJ. Multilobular osteochondrosarcoma of the canine skull: 16 cases (1978-1988). J Am Vet Med Assoc, 195:11764-9, 1989.
  3. Dernell WS, Straw RC, Cooper MF, Powers BE, LaRue SM, Withrow SJ. Multilobular osteochondrosarcoma in 39 dogs: 1979-1993. J Am Hosp Assoc, 24:111-118, 1998.
  4. Gallegos J, Scharz T, McAnuty JF. Massive midline occipitotemporal resection of the skull for treatment of multilobular osteochondrosarcoma in two dogs. J Am Vet Med Assoc, 233:752-757, 2008.
  5. Bryant KJ, Steinberg H, McAnulty JF. Cranioplasty by means of molded polymethylmethacrylate prosthetic reconstruction after radical excision of neoplasms of the skull in two dogs
  6. Rosselli DD, Platt SR, Freeman C, O’Neil J, Kent M, Holmes S. cranioplasty using titanium mesh after skull tumor resection in five dogs.
  7. Faissler D. Reconstructive cranioplasty of skull defects with titanium mesh and PMMA or the low-profile neuro system.  Proceedings 30th ECVN-ESVN symposium Helsinki, Finland, September 2017.
  8. Sweet KA, Nolan MW, Yoshikawa H, Gieger TL. Stereotactic radiation therapy for canine multilobular osteochondrosarcoma: Eight cases. Vet Comp Oncol, 2019, ahead of print
  9. Vancil JM, Henry CJ, Milner RJ, McCoig AM, Lattimer JC, Villamil J, McCaw DL, Bryan JN. Use of samarium Sm 153 lexidronam for the treatment of dogs with primary tumors of the skull: 20 cases (1986-2006). J Am Vet Med Assoc, 240:1310-1315, 2012.
  10. Holmes ME, Keyerleber MA, Faissler D. Prolonged survival after craniectomy with skull reconstruction and adjuvant definitive radiation therapy in three dogs with multilocular osteochondrosarcoma. Vet Radiol Ultrasound, 60:447-455, 2019.

Figure text

Figure 1 A-C: The CT images with a bone window illustrate the extensive nature of the mass. A) The sagittal view highlights the tumor extending from the frontal sinus to the parietal region of the skull. The mass has grown through the outer and inner cortex of the bone producing a moderately sized exostosis with associated marked brain compression. B) A transverse view at the level of the frontal sinus and frontal lobe of the brain shows a large destructive mass effect of the brain tissue. C) Another transverse view at the level of the hypophysis demonstrates the degree of brain compression

Figure 2:  A three-dimensional reconstruction of this bone mass shows the involvement of multiple skull structures including the frontal area, medio-caudal aspect of the orbit, and the parietal and temporal skull.

Figure 3: After complete resection of the bone mass a large defect including the entire frontal sinus area and the temporal bone of the skull on the left and right side had to be covered. Two large titanium plates were necessary to first produce a V-shaped implant over the temporal skull and then a second rhomboid shaped structure over the frontal sinus area.

Figure 4: The dog 11 months after surgery in very good general condition with a normal shape of the head